Border Terriers DNA testing

By Megan Chapel – Dogs Monthly

Good news for Border Terriers as The Kennel Club approves a new official DNA testing scheme for Spongiform LeucoEncephalMyelopathy (SLEM) in the breed.

The announcement follows a consultation with the breed health coordinator on behalf of the breed clubs. The DNA test is one three that have been recently released by the Animal Health Trust's (AHT's) Kennel Club Genetics Centre.

SLEM, sometimes referred to as 'shaking puppy syndrome', is a hereditary condition that can affect puppies from the time they begin attempting to walk. Those affected show severe tremors, mostly in the hind limbs. Scientists at the University of Missouri, the Animal Health Trust and at Wisdom Health, have now identified a mutation responsible for this disease in the Border Terrier.

Caroline Kisko, Kennel Club Secretary, said, "The Border Terrier is the tenth most popular breed in the UK so it is important that breeders have the tools needed to produce health dogs. This new DNA test will help to enable breeders in their efforts to eradicate shaking puppy syndrome in the breed by making sensible breeding decisions.

"The Border Terrier breed community is very health-focused and do a lot to protect and improve the breed's health, so we are pleased that the Kennel Club is now able to record the results of this test and can contribute towards protecting the future of this popular breed. This DNA test is a result of work carried out by the University of Missouri, supported by the team at the Kennel Club Genetics Centre at the Animal Health Trust and researchers at Wisdom Health, and we would encourage all breeders of Border Terrier to make use of this new test."

Dr Cathryn Mellersh, Head of Canine Genetics at the Animal Health Trust, added, "It has been a privilege to be able to collaborate on this research breakthrough which was led by Dr Ana Kolicheski and Dr Gary Johnson at the University of Missouri. My team were able to supply a number of DNA samples from affected cases in the UK, which helped to confirm that the mutation discovered in the US is the same mutation segregating in affected Border Terriers in the UK.

"It can be very difficult to identify the gene linked to an emerging neurological disease such as this, but the result is fantastic and we are very pleased to be able to quickly offer the DNA test at the AHT for the UK and European market. Now, there is no reason for any more Border Terriers to be born with shaking puppy syndrome, illustrating the enormous potential of DNA testing when implemented quickly and effectively across a breed."

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